Leicester City will be without striker Jamie Vardy and centre-back Caglar Soyuncu for their Europa League opener with Ukrainian side Zorya Luhansk.
Soyuncu, 24, could miss three months with an abductor injury he picked up on international duty with Turkey.
Top scorer Vardy, 33, has a calf issue and missed Sunday’s loss to Villa.
Forward Islam Slimani, 32, was left out of the European squad despite featuring for the first time since January 2018 on Sunday.
“There’s no doubt that with all the games that we’ll have to make changes. But our squad isn’t deep enough to make wholesale changes because of the number of injuries that we have,” said manager Brendan Rodgers.
On Slimani’s absence in the squad, he added:
“The squad had to be handed in much earlier than the Premier League squad and unfortunately, thinking maybe he [Slimani] wasn’t going to be here, that’s the reason why.”
Leicester will also be without midfielder Wilfred Ndidi, 23, who has a hip injury and Ricardo Pereira, 27, is a long-term absentee with an Achilles injury.